DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease
Identifieur interne : 002D42 ( Main/Exploration ); précédent : 002D41; suivant : 002D43DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease
Auteurs : K. Hedrich [Allemagne] ; A. Djarmati [Allemagne, Serbie] ; N. Sch Fer [Allemagne] ; R. Hering [Allemagne] ; C. Wellenbrock [Allemagne] ; P. H. Weiss [Allemagne] ; R. Hilker [Allemagne] ; P. Vieregge [Allemagne] ; L. J. Ozelius [États-Unis] ; P. Heutink [Pays-Bas] ; V. Bonifati [Pays-Bas, Italie] ; E. Schwinger [Allemagne] ; A. E. Lang [Canada] ; J. Noth [Allemagne] ; S. B. Bressman [États-Unis] ; P. P. Pramstaller [Italie] ; O. Riess [Allemagne] ; C. Klein [Allemagne]Source :
- Neurology [ 0028-3878 ] ; 2004.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background: Mutations in the Parkin gene (PARK2) are the most commonly identified cause of recessively inherited early-onset Parkinson disease (EOPD) but account for only a portion of cases. DJ-1 (PARK7) was recently reported as a second gene associated with recessively inherited PD with a homozygous exon deletion and a homozygous point mutation in two families. Methods: To investigate the frequency of DJ-1 mutations, the authors performed mutational analysis of all six coding exons of DJ-1 in 100 EOPD patients. For the detection of exon rearrangements, the authors developed a quantitative duplex PCR assay. Denaturing high performance liquid chromatography analysis was used to screen for point mutations and small deletions. Further, Parkin analysis was performed as previously described. Results: The authors identified two carriers of single heterozygous loss-of-function DJ-1 mutations, including a heterozygous deletion of exons 5 to 7 and an 11-base pair deletion, removing the invariant donor splice site in intron 5. Interestingly, both DJ-1 mutations identified in this study were found in the heterozygous state only. The authors also detected a polymorphism (R98Q) in 1.5% of the chromosomes in both the patient and control group. In the same patient sample, 17 cases were detected with mutations in the Parkin gene. Conclusions: Mutations in DJ-1 are less frequent than mutations in Parkin in EOPD patients but should be considered as a possible cause of EOPD. The effect of single heterozygous mutations in DJ-1 on the nigrostriatal system, as described for heterozygous changes in Parkin and PARK6, remains to be elucidated.
Affiliations:
- Allemagne, Canada, Italie, Pays-Bas, Serbie, États-Unis
- Latium, Ontario
- Rome, Toronto
- Université de Toronto
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Schwinger</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Human Genetics, University of Lübeck</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Department of Human Genetics, University of Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. 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Pramstaller</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Neurology, Regional General Hospital</s1><s2>Bolzano</s2><s3>ITA</s3><sZ>16 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Riess, O" sort="Riess, O" uniqKey="Riess O" first="O." last="Riess">O. Riess</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Medical Genetics, University Tubingen</s1><s3>DEU</s3><sZ>4 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University Tubingen</wicri:noRegion><wicri:noRegion>Department of Medical Genetics, University Tubingen</wicri:noRegion></affiliation></author><author><name sortKey="Klein, C" sort="Klein, C" uniqKey="Klein C" first="C." last="Klein">C. Klein</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Human Genetics, University of Lübeck</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Department of Human Genetics, University of Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Lübeck</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Department of Neurology, University of Lübeck</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">04-0362219</idno><date when="2004">2004</date><idno type="stanalyst">PASCAL 04-0362219 INIST</idno><idno type="RBID">Pascal:04-0362219</idno><idno type="wicri:Area/PascalFrancis/Corpus">000991</idno><idno type="wicri:Area/PascalFrancis/Curation">000332</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000891</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000891</idno><idno type="wicri:doubleKey">0028-3878:2004:Hedrich K:dj:park:mutations</idno><idno type="wicri:Area/Main/Merge">003113</idno><idno type="wicri:Area/Main/Curation">002D42</idno><idno type="wicri:Area/Main/Exploration">002D42</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease</title><author><name sortKey="Hedrich, K" sort="Hedrich, K" uniqKey="Hedrich K" first="K." last="Hedrich">K. Hedrich</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Human Genetics, University of Lübeck</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Department of Human Genetics, University of Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Lübeck</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Department of Neurology, University of Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Djarmati, A" sort="Djarmati, A" uniqKey="Djarmati A" first="A." last="Djarmati">A. Djarmati</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Human Genetics, University of Lübeck</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Department of Human Genetics, University of Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Lübeck</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Department of Neurology, University of Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Faculty of Biology, University of Belgrade</s1><s2>Serbia</s2><s3>YUG</s3><sZ>2 aut.</sZ></inist:fA14><country wicri:auto="YUG">Serbie</country><wicri:noRegion>Serbia</wicri:noRegion></affiliation></author><author><name sortKey="Sch Fer, N" sort="Sch Fer, N" uniqKey="Sch Fer N" first="N." last="Sch Fer">N. Sch Fer</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Human Genetics, University of Lübeck</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Department of Human Genetics, University of Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Lübeck</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Department of Neurology, University of Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Hering, R" sort="Hering, R" uniqKey="Hering R" first="R." last="Hering">R. Hering</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Medical Genetics, University Tubingen</s1><s3>DEU</s3><sZ>4 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University Tubingen</wicri:noRegion><wicri:noRegion>Department of Medical Genetics, University Tubingen</wicri:noRegion></affiliation></author><author><name sortKey="Wellenbrock, C" sort="Wellenbrock, C" uniqKey="Wellenbrock C" first="C." last="Wellenbrock">C. Wellenbrock</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Human Genetics, University of Lübeck</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Department of Human Genetics, University of Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Lübeck</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Department of Neurology, University of Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Weiss, P H" sort="Weiss, P H" uniqKey="Weiss P" first="P. H." last="Weiss">P. H. Weiss</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, University of Aachen</s1><s3>DEU</s3><sZ>6 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Aachen</wicri:noRegion><wicri:noRegion>Department of Neurology, University of Aachen</wicri:noRegion></affiliation></author><author><name sortKey="Hilker, R" sort="Hilker, R" uniqKey="Hilker R" first="R." last="Hilker">R. Hilker</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, University of Cologne</s1><s3>DEU</s3><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Cologne</wicri:noRegion><wicri:noRegion>Department of Neurology, University of Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Vieregge, P" sort="Vieregge, P" uniqKey="Vieregge P" first="P." last="Vieregge">P. Vieregge</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Lübeck</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Department of Neurology, University of Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Ozelius, L J" sort="Ozelius, L J" uniqKey="Ozelius L" first="L. J." last="Ozelius">L. J. Ozelius</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Molecular Genetics, Albert Einstein College of Medicine</s1><s2>Bronx, NY</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bronx, NY</wicri:noRegion></affiliation></author><author><name sortKey="Heutink, P" sort="Heutink, P" uniqKey="Heutink P" first="P." last="Heutink">P. Heutink</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Genetic-Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology & Biostatistics, Eramus Medical Center Rotterdam</s1><s3>NLD</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Genetic-Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology & Biostatistics, Eramus Medical Center Rotterdam</wicri:noRegion></affiliation></author><author><name sortKey="Bonifati, V" sort="Bonifati, V" uniqKey="Bonifati V" first="V." last="Bonifati">V. Bonifati</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Genetic-Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology & Biostatistics, Eramus Medical Center Rotterdam</s1><s3>NLD</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Genetic-Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology & Biostatistics, Eramus Medical Center Rotterdam</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Neurological Sciences, "La Sapienza" University</s1><s2>Rome</s2><s3>ITA</s3><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Schwinger, E" sort="Schwinger, E" uniqKey="Schwinger E" first="E." last="Schwinger">E. Schwinger</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Human Genetics, University of Lübeck</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Department of Human Genetics, University of Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Division of Neurology, Department of Medicine, University of Toronto, and Toronto Western Hospital</s1><s3>CAN</s3><sZ>13 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Division of Neurology, Department of Medicine, University of Toronto, and Toronto Western Hospital</wicri:noRegion><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Noth, J" sort="Noth, J" uniqKey="Noth J" first="J." last="Noth">J. Noth</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, University of Aachen</s1><s3>DEU</s3><sZ>6 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Aachen</wicri:noRegion><wicri:noRegion>Department of Neurology, University of Aachen</wicri:noRegion></affiliation></author><author><name sortKey="Bressman, S B" sort="Bressman, S B" uniqKey="Bressman S" first="S. B." last="Bressman">S. B. Bressman</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Neurology, Beth Israel Medical Center</s1><s2>New York, NY</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation></author><author><name sortKey="Pramstaller, P P" sort="Pramstaller, P P" uniqKey="Pramstaller P" first="P. P." last="Pramstaller">P. P. Pramstaller</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Neurology, Regional General Hospital</s1><s2>Bolzano</s2><s3>ITA</s3><sZ>16 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Riess, O" sort="Riess, O" uniqKey="Riess O" first="O." last="Riess">O. Riess</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Medical Genetics, University Tubingen</s1><s3>DEU</s3><sZ>4 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University Tubingen</wicri:noRegion><wicri:noRegion>Department of Medical Genetics, University Tubingen</wicri:noRegion></affiliation></author><author><name sortKey="Klein, C" sort="Klein, C" uniqKey="Klein C" first="C." last="Klein">C. Klein</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Human Genetics, University of Lübeck</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Department of Human Genetics, University of Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Lübeck</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Lübeck</wicri:noRegion><wicri:noRegion>Department of Neurology, University of Lübeck</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Mutation</term><term>Nervous system diseases</term><term>Parkin</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Mutation</term><term>Parkine</term><term>Système nerveux pathologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Mutations in the Parkin gene (PARK2) are the most commonly identified cause of recessively inherited early-onset Parkinson disease (EOPD) but account for only a portion of cases. DJ-1 (PARK7) was recently reported as a second gene associated with recessively inherited PD with a homozygous exon deletion and a homozygous point mutation in two families. Methods: To investigate the frequency of DJ-1 mutations, the authors performed mutational analysis of all six coding exons of DJ-1 in 100 EOPD patients. For the detection of exon rearrangements, the authors developed a quantitative duplex PCR assay. Denaturing high performance liquid chromatography analysis was used to screen for point mutations and small deletions. Further, Parkin analysis was performed as previously described. Results: The authors identified two carriers of single heterozygous loss-of-function DJ-1 mutations, including a heterozygous deletion of exons 5 to 7 and an 11-base pair deletion, removing the invariant donor splice site in intron 5. Interestingly, both DJ-1 mutations identified in this study were found in the heterozygous state only. The authors also detected a polymorphism (R98Q) in 1.5% of the chromosomes in both the patient and control group. In the same patient sample, 17 cases were detected with mutations in the Parkin gene. Conclusions: Mutations in DJ-1 are less frequent than mutations in Parkin in EOPD patients but should be considered as a possible cause of EOPD. The effect of single heterozygous mutations in DJ-1 on the nigrostriatal system, as described for heterozygous changes in Parkin and PARK6, remains to be elucidated.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Italie</li><li>Pays-Bas</li><li>Serbie</li><li>États-Unis</li></country><region><li>Latium</li><li>Ontario</li></region><settlement><li>Rome</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Hedrich, K" sort="Hedrich, K" uniqKey="Hedrich K" first="K." last="Hedrich">K. Hedrich</name></noRegion><name sortKey="Djarmati, A" sort="Djarmati, A" uniqKey="Djarmati A" first="A." last="Djarmati">A. Djarmati</name><name sortKey="Djarmati, A" sort="Djarmati, A" uniqKey="Djarmati A" first="A." last="Djarmati">A. Djarmati</name><name sortKey="Hedrich, K" sort="Hedrich, K" uniqKey="Hedrich K" first="K." last="Hedrich">K. Hedrich</name><name sortKey="Hering, R" sort="Hering, R" uniqKey="Hering R" first="R." last="Hering">R. Hering</name><name sortKey="Hilker, R" sort="Hilker, R" uniqKey="Hilker R" first="R." last="Hilker">R. Hilker</name><name sortKey="Klein, C" sort="Klein, C" uniqKey="Klein C" first="C." last="Klein">C. Klein</name><name sortKey="Klein, C" sort="Klein, C" uniqKey="Klein C" first="C." last="Klein">C. Klein</name><name sortKey="Noth, J" sort="Noth, J" uniqKey="Noth J" first="J." last="Noth">J. Noth</name><name sortKey="Riess, O" sort="Riess, O" uniqKey="Riess O" first="O." last="Riess">O. Riess</name><name sortKey="Sch Fer, N" sort="Sch Fer, N" uniqKey="Sch Fer N" first="N." last="Sch Fer">N. Sch Fer</name><name sortKey="Sch Fer, N" sort="Sch Fer, N" uniqKey="Sch Fer N" first="N." last="Sch Fer">N. Sch Fer</name><name sortKey="Schwinger, E" sort="Schwinger, E" uniqKey="Schwinger E" first="E." last="Schwinger">E. Schwinger</name><name sortKey="Vieregge, P" sort="Vieregge, P" uniqKey="Vieregge P" first="P." last="Vieregge">P. Vieregge</name><name sortKey="Weiss, P H" sort="Weiss, P H" uniqKey="Weiss P" first="P. H." last="Weiss">P. H. Weiss</name><name sortKey="Wellenbrock, C" sort="Wellenbrock, C" uniqKey="Wellenbrock C" first="C." last="Wellenbrock">C. Wellenbrock</name><name sortKey="Wellenbrock, C" sort="Wellenbrock, C" uniqKey="Wellenbrock C" first="C." last="Wellenbrock">C. Wellenbrock</name></country><country name="Serbie"><noRegion><name sortKey="Djarmati, A" sort="Djarmati, A" uniqKey="Djarmati A" first="A." last="Djarmati">A. Djarmati</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Ozelius, L J" sort="Ozelius, L J" uniqKey="Ozelius L" first="L. J." last="Ozelius">L. J. Ozelius</name></noRegion><name sortKey="Bressman, S B" sort="Bressman, S B" uniqKey="Bressman S" first="S. B." last="Bressman">S. B. Bressman</name></country><country name="Pays-Bas"><noRegion><name sortKey="Heutink, P" sort="Heutink, P" uniqKey="Heutink P" first="P." last="Heutink">P. Heutink</name></noRegion><name sortKey="Bonifati, V" sort="Bonifati, V" uniqKey="Bonifati V" first="V." last="Bonifati">V. Bonifati</name></country><country name="Italie"><region name="Latium"><name sortKey="Bonifati, V" sort="Bonifati, V" uniqKey="Bonifati V" first="V." last="Bonifati">V. Bonifati</name></region><name sortKey="Pramstaller, P P" sort="Pramstaller, P P" uniqKey="Pramstaller P" first="P. P." last="Pramstaller">P. P. Pramstaller</name></country><country name="Canada"><region name="Ontario"><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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